Immunotherapy and Cell Engineering Laboratory (ICEL)


Education

  • Ph.D. The University of Texas at Austin, 2010

Teaching Interests

Professor Singh's teaching interests encompass core mechanical engineering and biomedical engineering subjects at both undergraduate and graduate levels, including biofluids, immunoengineering, advanced materials, and cellular physiology. His instruction emphasizes fundamental principles and their application to engineering problems, fostering analytical and problem-solving skills. Professor Singh actively engages students in the learning process, integrating theoretical knowledge with practical insights to prepare them for advanced study and professional practice.

Research Interests

Professor Singh's research focuses on creating synthetic biomaterials-based “living” human immune tissues as organoids or on-chip to recapitulate structural and functional aspects of human immune system. Using mechanical, materials, and biomedical engineering principles, he studies cellular and biophysical crosstalk among tissues with immune cells and their tumors.

Recent Publications

  • Zhong Z, Quiñones-Pérez M, Dai Z, Juarez VM, Bhatia E, Carlson CR, Shah SB, Patel A, Fang Z, Hu T, Allam M, Hicks SL, Gupta M, Gupta SL, Weeks E, Vagelos SD, Molina A, Mulero-Russe A, Mora-Boza A, Joshi DJ, Sekaly RP, Sulchek T, Goudy SL, Wrammert J, Roy K, Boss JM, Coskun AF, Scharer CD, García AJ, Koff JL, Singh A. Human immune organoids to decode B cell response in healthy donors and patients with lymphoma. Nat Mater. 2025 Feb;24(2):297-311. PubMed Central PMCID: PMC11866935.
  • Ringquist R, Bhatia E, Chatterjee P, Maniar D, Fang Z, Franz P, Kramer L, Ghoshal D, Sonthi N, Downey E, Canlas J, Ochal A, Agarwal S, Cuéllar V, Harrigan G, Coskun AF, Singh A, Roy K. An immune-competent lung-on-a-chip for modelling the human severe influenza infection response. Nat Biomed Eng. 2025 Sep 23; PubMed PMID: 40987954.
  • Shah SB, Carlson CR, Lai K, Zhong Z, Marsico G, Lee KM, Félix Vélez NE, Abeles EB, Allam M, Hu T, Walter LD, Martin KE, Gandhi K, Butler SD, Puri R, McCleary-Wheeler AL, Tam W, Elemento O, Takata K, Steidl C, Scott DW, Fontan L, Ueno H, Cosgrove BD, Inghirami G, García AJ, Coskun AF, Koff JL, Melnick A, Singh A. Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas. Nat Mater. 2023 Apr;22(4):511-523. PubMed Central PMCID: PMC10069918.
  • Yee Mon KJ, Kim S, Dai Z, West JD, Zhu H, Jain R, Grimson A, Rudd BD, Singh A. Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells. Nat Nanotechnol. 2024 Aug;19(8):1190-1202. PubMed Central PMCID:PMC11330359.
  • Mora-Boza A, Mulero-Russe A, Di Caprio N, Burdick JA, O'Neill E, Singh A, García AJ. Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems. Nat Protoc. 2025 Jan;20(1):272-292. PubMed PMID: 39266725.