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Education

  • Ph.D., Clarkson University, 1985
  • M.S., Rensselaer Polytechnic Institute, 1980
  • B.S., Rensselaer Polytechnic Institute, 1978

Background

Dr. Aidun joined the Woodruff School as a Professor in 2003 after completion of a two-year period as program director at the National Science Foundation. He began at Tech in 1988 as an Assistant Professor at the Institute of Paper Science and Technology. Prior, he was a research Scientist at Battelle Research Laboratories, Postdoctoral Associate at Cornell University and Senior Research Consultant at the National Science Foundation's Supercomputer Center at Cornell. 

Research

  • Fluid Mechanics; cellular blood flow, suspension hydrodynamics, flow instability
  • BioEngineering;  platelet margination,  shear-induced thrombosis, clonal propagation by somatic embryogenesis 
  • Energy; industrial decarbonization 

Dr. Aidun's research is at the intersection between fundamentals of the physics of complex fluids/thermal transport and applications to engineering and biotransport. He has a diverse research portfolio in fluid mechanics, bioengineering, renewable bioproducts and decarbonization of industrial processes. 

A major focus has been to understand the physics of blood cell transport and interaction with glycoproteins (e.g., vWF) with applications to cardiovascular diseases.

 

Dr. Aidun has pioneered the development of the Lattice-Boltzmann (LB) method for suspension hydrodynamics and nonlinear dynamical systems. It is now well established that the LB method, based on the solution of discrete Boltzmann equation, is a superior computational method for hard particles as well as transport of deformable capsules and particle. These methods open the possibility for mechanical, thermal and rheological analyses of a broad class of deformable particle/fiber suspension flows. 

Novel computational methods for direct numerical simulation (DNS) of suspension hydrodynamics including fiber suspension, biotransport and whole blood flow are ongoing research areas.

Fluidics-based automation of sorting and selection of somatic embryogenesis for clonal propagation of plants is another are of active research. 

Engineering applications are primarily in the decarbonization of industrial process through major process modifications. This is an area of growth with major funding from the Department of Energy and industrial collaborators. 

Dr. Aidun is the recipient of several National and international awards including the National Science Foundation Presidential Investigator award, The Gunnar Nicholson Fellowship and the International Society of Coating Science and Technology’s L. E. Scriven award. 

Selected Patents

  • Aidun, CK; 10827694 "Plant propagule root-growing device," Nov 10, 2022. 
  • Aidun, CK; 9040301“Separator Device, System for...Somatic Plant Embryos”May 26, 2015. 
  • Aidun, CK; 8975077“Methods for dispersing somatic plant embryos”Mar10, 2015. 
  • Aidun & Egertsdotter; 8927287 “Method for Dispersion of Assemblies of Biological Samples” Jan. 6, 2015. 
  • Aidun, CK; 8452460 “Fluidics-based Orientation and Sorting for Plant Embryos” May 28, 2013. 
  • Aidun & Sozer; 7745204 “Automation of Biological Sample Aliquoting” June 29, 2010. 

Representative Publications

Cellular Blood Flow and high-shear thrombosis 

  • Liu, ZL, Ku, DN and Aidun, CK, "Mechanobiology of shear-induced platelet aggregation leading to occlusive arterial thrombosis: A multiscale in silico analysis," J. Biomechanics,120,110349, 2021. 

  • Liu, ZL,Bresette, C, Aidun, CK, and Ku, DN, "SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear," Blood Advances, 2021. 

  • Madukauwa-David, I, Sadri, V, Midha, P, Babaliaros, V, Aidun, C, Yoganathan, A "An Evaluation of the Influence of Coronary Flow on Transcatheter Heart Valve Neo-Sinus Flow Stasis," Annals of Biomedical Engineering, 48 (1), 169-180, 2020 

  • Liu, Z, Clausen, JR, Rao, RR, Aidun, CK,, " Nanoparticle diffusion in sheared cellular blood flow," J. Fluid Mech.871, 636-667, 2019. 

  • Ahmed, F., M Mehrabadi, Z Liu, GA Barabino, CK Aidun, "Internal Viscosity-Dependent Margination of Red Blood Cells in Microfluidic Channels" J. Biomechanical Engineering,140(6), 061013, 2018.12. 

  • Griffin, MT Y Zhu, Z Liu, CK Aidun, DN Ku " Inhibition of high shear arterial thrombosis by charged nanoparticles MT ",J. Biomicrofluidics, 12, 4, pp. 042210, 2018. 

  • Mehrabadi, M, Ku, DN, Aidun, CK “Effects of shear rate, confinement, and particle parameterson marginationin blood flow,” Physical Review E  93 (2), 023109, 2016. 

  • Mehrabadi, M., Casa, LDC, Aidun, CK, Ku, DN, “A predictive model of high shear thrombus growth,” Annals of Biomedical Engineering,44(8),2339-2350, 2016. 

  • Mehrabadi, M, Ku, D, and Aidun, CK,“A Continuum Model for Platelet Transport in Flowing Blood Based on Direct Numerical Simulations of Cellular Blood Flow,” Annals of BiomedicalEngineering,43 (6), 1410-1421, 2015.26. 

  • Yun, BM, McElhinney, D, Arjunon, S, Mirabella, L, Aidun, CK, Yoganathan,A, “Computational simulations of flow dynamics and blood damage through a bileaflet mechanical heart valve scaled to pediatric size and flow,” J Biomechanics, June 2014. 

  • Yun,BM, Desai, P, Aidun, CK,Yoganathan, A, “Highly resolved pulsatile flows through bileflaet mechanical heart valves using the lattice-Boltzmann method,” J. Fluid Mech., 754, 122-160, 2014. 

  •  Yun,BM, Desai, P, Aidun, CK, and Yoganathan, A, “Computational modeling of flow through bileaflet mechanical heart valves using the entropic lattice-Boltzmann method” J. Fluid Mech.,743, 170-201, 2014. 

  • Yun, M., Aidun, C.K., Yoganathan, A., “Blood damage through a bileaflet mechanical heartvalve: a quantitative computational study using a multiscale suspension flow solver,”J.Biomechanical Eng., 136, 101009, 1-17, 2014. 

  • Reasor, D., Clausen, J., and Aidun C.K., “Rheological characterization of cellular blood inshear,”J. Fluid Mech., 726, 497-516, 2013. 

  • Reasor D.A., Mehrabadi M., Ku D.N., and Aidun C.K., “Determination of Critical Parameters in Platelet Margination,” Annals of Biomedical Engineering, (DOI: 10.1007/s10439-012-0648-7) online 2012. 

  • Yun M.,  Wu J., Simon H., Arjunon S., Sotiropoulos F., Aidun C.K., Yoganathan A.,  "Blood damage in the hinge of a bileaflet mechanical heart valve," Annals of Biomedical Engineering, 40 (7), pp. 1468–1485, 2012. 

  • Wu J., Yun B.M., Fallon A.M., Hanson S.R., Aidun C.K., and Yoganathan A.P., "Numerical Investigation of the Effects of Channel Geometry on Platelet Activation and Blood Damage," Annals of Biomedical Engineering, 39 (2), pp. 897-910, 2011. 

  • Clausen J.R., Reasor D.A., and Aidun C.K., “Parallel Performance of a Lattice-Boltzmann/Finite Element Cellular Blood Flow Solver on the IBM Blue Gene/P Architecture,” Computer Physics Comm., 181 (6), 1013-1020, 2010. 

Suspended particles with inertia 

  • Rosén, T, Do-Quang, M, Aidun, CK, and Lundell,F, “Effect of fluid and particle inertia on the rotation of an oblate spheroidal particle suspended in linear shear flow,” Physical Review E  91(5), 053017, 2015. 

  • Rosén, T, Quang, M, Aidun, CK, and Lundell, F, “The combined effect from fluid and particle inertia on the dynamical states of a prolate spheroidal particle suspended in shear flow,”J. FluidMech., 771, 115-158, 2015. 

  • Rosén, T., Lundell, F., and Aidun, C.K., “effect of fluid inertia on the dynamics and scaling of neutrally buoyant particles in shear flow” J. Fluid Mech., 738, 563-590, 2014. 

  • Ding, E-J., and Aidun, C. K., “ The Dynamics and Scaling Law for Particles Suspended in Shear Flow with Inertia,” J. Fluid Mech., 423, 317-344, 2000.

Deformable fibers and capsules 

  • Salahuddin, A., Wu, J., and Aidun, C.K., “Study of semidilute fibre suspension rheology with lattice-Boltzmann method,”Rheologica Acta, 52 (10-12), 891-902, 2013 

  • Salahuddin A., Wu J., and Aidun, C.K., “Numerical study of rotational diffusion in sheared semidilute fibre suspension,”  J. Fluid. Mech., 692, 153-182, 2012.  

  • Clausen J., Reasor D., and Aidun C.K., “The rheology and microstructure of concentrated non-colloidal suspensions of deformable capsules,” J. Fluid Mech., 685, 202-234, 2011. 

  • Khan I. and Aidun, C.K., “Direct numerical simulation of saturated deformable porous media using parallel hybrid Lattice–Boltzmann and finite element method” International J Num. Methods in Eng., 86 (12), 1379-95, 2011. 

  • Clausen J. R., and Aidun C.K., “Capsule dynamics and rheology in shear flow: Particle pressure and normal stress,” Phys Fluid, 22 (12) pp. 123302-123302-11, 2010.  

  • Wu J. and Aidun C.K., “A numerical study of the effect of fiber stiffness on the rheology of sheared flexible fiber suspensions, J. Fluid Mech., 662, pp. 123–133, 2010.

Lattice-Boltzmann method for fluid flow and heat transfer

  • Aidun C.K. and Clausen J.R., “Lattice-Boltzmann method for Complex Flows,” Annul Review Fluid Mech., 42, 439-72, 2010. 

  • Khiabani R., Joshi Y., and Aidun C.K., “Heat Transfer in Microchannels with Squeeze flow,”  Int. J. Heat and Mass Transfer, 53 (19), 4039-4046, 2010. 

  • Khiabani R., Joshi Y., and Aidun C.K., “Heat Transfer in Microchannels with Suspended Solid Particles: Lattice-Boltzmann Based Computations,”  J. Heat Transfer, 132 (4), 2010. 

  • MacMeccan, R., Clausen, J., Neitzel, P., and Aidun, C.K., “Simulating deformable particle suspensions using a coupled lattice-Boltzmann and finite-element method,” J. Fluid Mech., 618, 13-39, 2009. 

  • Ding E.J., and Aidun C.K., “Extension of the Lattice-Boltzmann Method for Direct Simulation of Suspended Particles Near Contact,” J. Statistical Physics 112, 685, 2003. 

  • Aidun C.K., Ding E.J., and Lu Y. “Direct Analysis of Particulate with Inertia Using the Discrete Boltzmann Equations”  J. Fluid Mech., 373, 287, 1998.

Somatic Embryogenesis

  • Mamun, NHA, Aidun, CK, Egertsdotter, U-"Improved and synchronized maturation of Norway spruce (Picea abies (L.) H. Karst.) somatic embryos in temporary immersion bioreactors" In Vitro Cellular& Developmental Biology-Plant, 54 (6), pp. 612-620, 2018. 

  • Mamun, NH, Egertsdotter, UEG, Aidun, CK, “Bioreactor technology for clonal propagation of plants and metabolite production,” Frontiers in Biology, 10 (2), 177-193, 2015. 

  • Carrick, C., Larsson, PA., Brismar, H., Aidun, CK, and Wågberg, L, “Native and functionalized micrometre-sized cellulose capsules prepared by microfluidic flow focusing,” RSC Advances 4(37), 19061-19067, 2014. 

  • Sun H., Aidun C.K., and Egertsdotter E-M U, “Possible effect from shear stress on maturation of somatic embryos of Norway Spruce (Picea Abies),” Biotechnology and Bioengineering, 109 (5), 1089-99, 2011. 

  • Sun, H., Aidun, C.K., Egertsdotter, E-M U., “Effects from shear stress on morphology and growth of early stages of Norway spruce somatic embryos”,  Biotechnology and Bioengineering 105 (3), 588-99, 2010.